This is a list/research dump on amanita muscaria and related. I will keep adding to it.
I'll clean this page up better when I have time.
Historical Research and use as a flavoring
https://pubs.acs.org/doi/pdf/10.1021/ba-1966-0056.ch015
https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1970-01-01_4_page005.html
(This pulls historical research and breaks down the chemistry of each isolated therapeutic derivative)
https://www.mdpi.com/2673-8392/1/3/69
Ibotenic acid/muscimol in the body post 2017
Depression Treatment
https://www.sciencedirect.com/science/article/abs/pii/S0367326X23001958
Boosting Dopamine ( depression, addictions)
https://pubmed.ncbi.nlm.nih.gov/7449921/
Noradrenaline, Serotonin
https://link.springer.com/article/10.1007/bf00402378
Epilepsy and Tremors
Alzheimers
https://www.sciencedirect.com/science/article/pii/S0924977X23001347
Brain and Body conversions post 2017
https://metacyc.org/gene?orgid=META&id=G-80777
Vanadium and it's concentrations including stipes
https://pubs.rsc.org/en/content/articlelanding/2021/ja/d0ja00518e
https://www.sciencedirect.com/science/article/abs/pii/S0010854513000647
Role in the body
Pain
https://www.epain.org/journal/view.html?doi=10.3344/kjp.23161
Inflammation
https://pubmed.ncbi.nlm.nih.gov/35856422/
Cognitive Issues
https://pubmed.ncbi.nlm.nih.gov/29133125/
The Liver/Neuronal Synapses
https://www.mdpi.com/1420-3049/28/19/6824
Blood Brain Barrier
Muscimol in the body outside of GABA
Prolactin and Growth Hormone
Muscaria Bias
Rubel, W.; Arora, D. A Study of Cultural Bias in Field Guide Determinations of Mushroom Edibility Using the Iconic Mushroom, Amanita muscaria, as an Example. Econ. Bot. 2008, 62, 223–243. [Google Scholar] [CrossRef]
Muscimol's effects on GABA pathways and subpathways
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823376/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551397/
https://pubmed.ncbi.nlm.nih.gov/24473816/
Multiple forms of ibotenic acid
https://en.wikipedia.org/wiki/Ibotenic_acid
Biosynthesis of Ibo/Muscimol within the mushroom
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383597/
https://www.hindawi.com/journals/jchem/2020/8859998/
Størmer, F.C.; Janak, K.; Koller, G.E.B. Ibotenic Acid in Amanita muscaria Spores and Caps. Mycologist 2004, 18, 114–117. [Google Scholar] [CrossRef]
Forms
https://pubs.acs.org/doi/abs/10.1021/jm50001a022
The heart and Muscarinic Receptors
https://pubmed.ncbi.nlm.nih.gov/9874168/
https://pubmed.ncbi.nlm.nih.gov/22222704/
Storage and Actives
Converting ibo to muscimol by boiling, by bacteria- Trent Austin patent + any subsequent research on this post 2017 (none outside of one paper).
https://patents.google.com/patent/US20140004084A1/en
https://link.springer.com/article/10.1007/s10967-018-6203-8
Concentrations of muscarine in amanita muscaria mushrooms
Positive uses of muscarine in our body
ibotenic acid to muscazone conversion
Theoretical Description for Ibotenic Acid and Muscazone Determination ... https://biointerfaceresearch.com/wp-content/uploads/2022/07/BRIAC133.275.pdf
Stipe Concentrations
Different stages of growth and concentrations
https://www.hindawi.com/journals/jchem/2020/8859998/
Cholinergics
https://psycnet.apa.org/record/1995-36006-001
https://onlinelibrary.wiley.com/doi/10.1111/jnc.15683
https://www.mdpi.com/2076-3425/13/6/917
https://pubmed.ncbi.nlm.nih.gov/1611500/
https://www.poison.org/-/media/files/aapcc-annual-reports/npds2004.pdf (see pg 70)
https://namyco.org/docs/CountAchilles.pdf
More studies on poisonings:
This was copy/pasted from the description of my video on Ibotenic acid where I defend my stance on it. I just left it here in case people don't watch the videos.
Łukasik-Głebocka, M.; Druzdz, A.; Naskret, M. Clinical symptoms and circumstances of acute poisonings with fly agaric (Amanita muscaria) and panther cap (Amanita pantherina). Prz. Lek. 2011, 68, 449–452. [Google Scholar]
Rampolli, F.I.; Kamler, P.; Carnevale Carlino, C.; Bedussi, F. The Deceptive Mushroom: Accidental Amanita muscaria Poisoning. Eur. J. Case Rep. Intern. Med. 2021, 8, 002212. [Google Scholar] [CrossRef]
Mikaszewska-Sokolewicz, M.A.; Pankowska, S.; Janiak, M.; Pruszczyk, P.; Łazowski, T.; Jankowski, K. Coma in the Course of Severe Poisoning after Consumption of Red Fly Agaric (Amanita muscaria). Acta Biochim. Pol. 2016, 63. [Google Scholar] [CrossRef]
This is my notes and discussion on this study, keep scrolling for more citations.
The Toxicological Pathologic Study of Amanita muscaria in Sprague-Dawley Rat
AND interestingly they found NO damage to the brain even though it was injected which lends creedence to what I have continued to say, injecting it straight into a brain is not the same thing as ingesting it. I will continue to claim personally that it is NOT toxic at low and reasonable doses. i posted here before on Ibotenic acid and defended this claim. WTF is science's obsession with injecting shit FFS?
I am skeptical of this study when they do like many researchers and discuss at great length, the amatoxins in the deadly amanitas then jump right into discussing how they are going to test muscaria. These are two different living things, with different morphologies and physiologies. Muscariods to do not have amatoxins. It is irresponsible science. When they do that, I immediately am skeptical of the rest of the study. Not only because if they can’t get the introduction right, what else did they not do correctly?
"Amanita muscaria appears to be the most toxic in appearance, with muscarine and bufotenine being the main constituents causing vomiting and diarrhea and exhibiting neuropsychological and psychological effects by muscarine [7,18]"
Saying muscaria appears to be the most toxic is just nonsense. They cite numbers 7 and 18 in their citations for claiming muscarine and bufotenine are the main constituents causing sickness. Number 7 doesn’t mention muscaroids or muscarine. Number 18 again discusses the class of amanitins, and nothing in that publications mentions muscarine or bufotenine. It was established long ago that muscarine is not the main toxin responsible for gastric issues in the muscaroids. There is no date on this research but they cite research from 2007 so it is at least reasonable to expect some simple research into the actual toxin here. There are only trace amounts of muscarine in muscaroids. Not saying it can’t cause issues, but their claims of it being the main toxin are decades old and wrong. And bufotenine? Seriously? This is not in amanita muscaria.
They bought amanita muscaria and extracted at room temp using a buffered solution so that no decarb would take place. This means it was mostly ibotenic acid that they are testing.
In the results and discussion they write about ibotenic acid in para 7.
In the next paragraph they write this:
The blood analysis values of the administration group were significantly different from those of the control group, and all of the SD rats used in the experiment were observed to have no abnormality in health. The mushroom poisoning showed fulminant hepatic necrosis and acute renal failure due to amatoxin, a deadly toxin contained in mushrooms. So now it’s amatoxins they administered?
Under the histopathological section, they state that no brain lesions were found. This is not what all previous studies have said about ibo being neurotoxic but those were injected into the brains. It seems injection into the body creates a different physiology (which I think we all expected).
They go on to state:
There are many ways to classify poisons, but according to the symptoms, they are classified into seven groups, each of which exhibits characteristic latent period, target organ, and clinical symptoms [16,18,24]. The symptoms of poisoning by poisonous mushrooms vary according to the toxic substances contained in the mushroom, and the mushrooms contain a variety of chemical components. Poisoning toxicity is mainly caused by A. phalloides, A. virosa, and A. verna in the genus Amanita, phalloidin and amatoxin in the mushroom contain two types of poisons. Phalloidin acts on the actin polymerase-depolymerase cycle, which causes cell membrane dysfunction, but this is not clinically important. Amatoxin inhibits nucleoplasmic RNA polymerase, Inhibits protein synthesis and can cause necrosis of intestinal epithelial cells, hepatocytes, and kidney tubular cells [2,4,18,21]. Histopathological examination of SD rats repeatedly administered for 3 weeks or more showed degeneration and division of pericytes in the liver tissue. However, A. muscaria seems to induce toxic pathologic lesions in the liver when repeatedly administered over a long period of time, considering that damaged tissues can not be found in the liver tissues of SD rats that were autopsied 1 week and 2 weeks after administration. Serum BUN and creatinine levels were normal in the kidney, but histopathological examination revealed the infiltration of inflammatory cells and necrosis of tubular epithelial cells.
Again mixing amatoxins with ibotenic acid.
I believe they may have ordered amanita muscaria, especially if that’s what they wanted to study. And it may be possible that’s what they used for this study and that means the actual data may be accurate. IF SO then it seems there’s no brain issues but there are with liver and kidney after 3 weeks of heavy use of dried amanita extracted at room temp and ph controlled.
Long term ingestion:
A. muscaria was administered at a concentration of 16.5 mg/kg twice a week for 4 weeks. If my math is right that’s:
16.5 mg = .0164g per kg
So for me=
I am 56 kilograms times 16.5 mg= 924mg, that’s almost a gram
150 pound person= 68kg
68kg X .0164g = 1.11 grams twice a week for 4 weeks. This is ibotenic acid.
I know people who microdose ibotenic acid for ADD and I smoke the mushroom but have no idea how much decarb happens when it’s burned like that. The people I know microdosing it take 1/5 that. So some dose studies are needed now. I have been asking for this kind of information for a while now. My problem is they seem to lump all toxic amanita together and didn’t even know what toxic thing they were studying. So, still a long way to go. Maybe there’s a bias in the scientific community for ibotenic acid studies and this was a way to get around that. IDK
The other issue is that they made an extract we have no idea how to dose it. Is this 15.5 of the extract they made? If so, it is highly concentrated and there’s no equivalency given. There is no way to equate this study to anything or to cross it to humans when the dosing isn’t clear nor is it clear what toxin they used.
This following study is from 2020 and is about Glutamate toxicity and in the pre-study discussion it gives details about the history of the use excitotoxins including ibotenic acid so you can see all of the different excitotoxins science has used, what they do and why ibotenic acid is being used, still injected into brains.
https://www.frontiersin.org/articles/10.3389/fnins.2020.00927/full
IBOTENIC ACID AS MEDICINE
VanPatten, S.; Al-Abed, Y. The Challenges of Modulating the ‘Rest and Digest’ System: Acetylcholine Receptors as Drug Targets. Drug Discov. Today 2017, 22, 97–104. [Google Scholar]
https://www.frontiersin.org/articles/10.3389/fnmol.2016.00028/full
Also, if they are causing lesions by injection through the cholinergic pathways, it is affecting the cholinergic pathways, as discussed here, with the opening statements:
The neurotoxic effects produced by ibotenic acid (IA) induced chemical lesions of the central nervous system (CNS) cholinergic system were examined on the opioid peptidergic system in adult rats. Forebrain cholinergic systems were bilaterally lesioned by the infusion of IA (1 or 5 micrograms/site) into the nucleus basalis magnocellularis (NBM). One week after the injections, the animals were sacrificed, and activities of acetylcholinesterase (AChE), choline acetyltransferase (ChAT) and concentrations of beta-endorphin (beta-End) and Met-enkephalin (Met-Enk) were measured in different brain regions.
https://psycnet.apa.org/record/1995-36006-001
The major effects that we know of from ibotenic acid are the spasms in both smooth and skeletal muscle in higher doses. Spasms are caused via the cholinergic pathways and diseases that cause spasms like parkinson's and dystrophies etc are diseases of the cholinergic pathways.
https://www.ncbi.nlm.nih.gov/books/NBK526134/
https://link.springer.com/article/10.1007/s11062-005-0034-2
Showing no brain lesions with muscular injection.
Injection Studies
https://link.springer.com/article/10.1007/BF00236800
https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/ibotenic-acid
https://www.sciencedirect.com/science/article/abs/pii/0165027089901490
Metabolism and Neurobiology
https://libgen.is/scimag/10.1002%2Fbip.21416
https://www.frontiersin.org/articles/10.3389/fphar.2023.1102465/full
https://pubs.acs.org/doi/pdf/10.1021/jm50001a022
https://www.sciencedirect.com/science/article/abs/pii/S0014299903028395
https://www.sciencedirect.com/science/article/abs/pii/S0278691519304764
https://www.frontiersin.org/articles/10.3389/fnins.2020.00927/full
https://www.sciencedirect.com/topics/neuroscience/muscimol
https://www.acnp.org/g4/GN401000008/Default.htm
https://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1970-01-01_4_page005.html
https://www.mdpi.com/1420-3049/28/19/6824
Preparation
https://www.tandfonline.com/doi/abs/10.1080/02791072.2010.10400712
https://www.tandfonline.com/doi/abs/10.1080/10826079708010660
https://pubs.rsc.org/en/content/articlelanding/1922/ct/ct9222101743/unauth
https://patents.google.com/patent/US20140004084A1/en
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133115/
https://link.springer.com/article/10.1007/s11356-021-14740-6
https://www.sciencedirect.com/science/article/abs/pii/S0953756208611582?via%3Dihub
Death and Adverse Events
https://www.sciencedirect.com/science/article/abs/pii/S0041010105000188
https://www.sciencedirect.com/science/article/abs/pii/S0041010114002967
http://ojs.ptbioch.edu.pl/index.php/abp/article/view/1694
https://www.bayareamushrooms.org/education/further_reflections_amanita_muscaria.html
https://www.cdc.gov/mmwr/volumes/68/wr/mm6821a4.htm
https://pubmed.ncbi.nlm.nih.gov/30073844/
The Following is a huge dump of research someone compiled in my old forum, just copy and pasted here. It's messy, some irrelevant. I just put it here in case anyone wants to go through it.
Rubel, W.; Arora, D. A Study of Cultural Bias in Field Guide Determinations of Mushroom Edibility Using the Iconic Mushroom, Amanita muscaria, as an Example. Econ. Bot. 2008, 62, 223–243. [Google Scholar] [CrossRef]
Whelan, C. “Amanita muscaria”: The Gorgeous Mushroom. Asian Folk. Stud. 1994, 53, 163. [Google Scholar] [CrossRef]
Infraspecific Taxa of Muscaria. Available online: Amanitaceae.org (accessed on 16 August 2021).
Gillard, R.D.; Lancashire, R.J. Electron Spin Resonance of Vanadium in Amanita muscaria. Phytochemistry 1984, 23, 179–180. [Google Scholar] [CrossRef]
Michelot, D.; Melendez-Howell, L.M. Amanita muscaria: Chemistry, Biology, Toxicology, and Ethnomycology. Mycol. Res. 2003, 107, 131–146. [Google Scholar] [CrossRef] [PubMed]
Li, D.-W. Release and Dispersal of Basidiospores from Amanita muscaria var. Alba and Their Infiltration into a Residence. Mycol. Res. 2005, 109, 1235–1242. [Google Scholar] [CrossRef]
Li, Q.; He, X.; Ren, Y.; Xiong, C.; Jin, X.; Peng, L.; Huang, W. Comparative Mitogenome Analysis Reveals Mitochondrial Genome Differentiation in Ectomycorrhizal and Asymbiotic Amanita Species. Front. Microbiol. 2020, 11, 1382. [Google Scholar] [CrossRef] [PubMed]
Falandysz, J.; Treu, R. Amanita muscaria: Bio-Concentration and Bio-Indicative Potential for Metallic Elements. Environ. Earth Sci. 2019, 78, 722. [Google Scholar] [CrossRef]
Willmann, A.; Weiß, M.; Nehls, U. Ectomycorrhiza-Mediated Repression of the High-Affinity Ammonium Importer Gene AmAMT2 in Amanita muscaria. Curr. Genet. 2007, 51, 71–78.
Geml, J.; Laursen, G.A.; O’Neill, K.; Nusbaum, H.C.; Taylor, D.L. Beringian Origins and Cryptic Speciation Events in the Fly Agaric (Amanita muscaria): Phylogeography of Amanita muscaria. Mol. Ecol. 2005, 15, 225–239. [Google Scholar] [CrossRef] [PubMed]
Di Rita, F.; Atzeni, M.; Tudino, F. The History of Conifers in Central Italy Supports Long-Term Persistence and Adaptation of Mesophilous Conifer Fungi in Arbutus-Dominated Shrublands. Rev. Palaeobot. Palynol. 2020, 282, 104300. [Google Scholar] [CrossRef]
Bagley, S.J.; Orlovich, D.A. Genet Size and Distribution of Amanita muscaria in a Suburban Park, Dunedin, New Zealand. N. Z. J. Bot. 2004, 42, 939–947. [Google Scholar] [CrossRef]
Nouhra, E.R.; Palfner, G.; Kuhar, F.; Pastor, N.; Smith, M.E. Ectomycorrhizal Fungi in South America: Their Diversity in Past, Present and Future Research. In Mycorrhizal Fungi in South America; Pagano, M.C., Lugo, M.A., Eds.; Fungal Biology; Springer International Publishing: Cham, Switzerland, 2019; pp. 73–95. ISBN 978-3-030-15227-7. [Google Scholar]
Reid, D.A.; Eicker, A. South African Fungi: The Genus Amanita. Mycol. Res. 1991, 95, 80–95. [Google Scholar] [CrossRef]
Sawyer, N.A.; Chambers, S.M.; Cairney, J.W.G. Distribution and Persistence of Amanita muscaria Genotypes in Australian Pinus radiata Plantations. Mycol. Res. 2001, 105, 966–970. [Google Scholar] [CrossRef]
Vargas, N.; Gonçalves, S.C.; Franco-Molano, A.E.; Restrepo, S.; Pringle, A. In Colombia the Eurasian Fungus Amanita muscaria Is Expanding Its Range into Native, Tropical Quercus humboldtii Forests. Mycologia 2019, 111, 758–771. [Google Scholar] [CrossRef]
Deja, S.; Wieczorek, P.P.; Halama, M.; Jasicka-Misiak, I.; Kafarski, P.; Poliwoda, A.; Młynarz, P. Do Differences in Chemical Composition of Stem and Cap of Amanita muscaria Fruiting Bodies Correlate with Topsoil Type? PLoS ONE 2014, 9, e104084. [Google Scholar] [CrossRef]
Metals in Amanita muscaria
Braeuer, S.; Walenta, M.; Steiner, L.; Goessler, W. Determination of the Naturally Occurring Vanadium-Complex Amavadin in Amanita muscaria with HPLC-ICPMS. J. Anal. At. Spectrom. 2021, 36, 954–967. [Google Scholar] [CrossRef]
Housecroft, C.E. The Fungus Amanita muscaria: From Neurotoxins to Vanadium Accumulation. Chimia 2019, 73, 96–97.
Falandysz, J.; Hanć, A.; Barałkiewicz, D.; Zhang, J.; Treu, R. Metallic and Metalloid Elements in Various Developmental Stages of Amanita muscaria (L.) Lam. Fungal Biol. 2020, 124, 174–182. [Google Scholar] [CrossRef] [PubMed]
Falandysz, J.; Saniewski, M.; Zalewska, T.; Zhang, J. Radiocaesium Pollution of Fly Agaric Amanita muscaria in Fruiting Bodies Decreases with Developmental Stage. Isot. Environ. Health Stud. 2019, 55, 317–324. [Google Scholar] [CrossRef]
Toxicology
Beuhler, M.C. Overview of Mushroom Poisoning. In Critical Care Toxicology; Brent, J., Burkhart, K., Dargan, P., Hatten, B., Megarbane, B., Palmer, R., Eds.; Springer International Publishing: Cham, Switzerland, 2016; pp. 1–26. ISBN 978-3-319-20790-2. [Google Scholar]
Łukasik-Głebocka, M.; Druzdz, A.; Naskret, M. Clinical symptoms and circumstances of acute poisonings with fly agaric (Amanita muscaria) and panther cap (Amanita pantherina). Prz. Lek. 2011, 68, 449–452. [Google Scholar]
Rampolli, F.I.; Kamler, P.; Carnevale Carlino, C.; Bedussi, F. The Deceptive Mushroom: Accidental Amanita muscaria Poisoning. Eur. J. Case Rep. Intern. Med. 2021, 8, 002212. [Google Scholar] [CrossRef]
Mikaszewska-Sokolewicz, M.A.; Pankowska, S.; Janiak, M.; Pruszczyk, P.; Łazowski, T.; Jankowski, K. Coma in the Course of Severe Poisoning after Consumption of Red Fly Agaric (Amanita muscaria). Acta Biochim. Pol. 2016, 63. [Google Scholar] [CrossRef]
VanPatten, S.; Al-Abed, Y. The Challenges of Modulating the ‘Rest and Digest’ System: Acetylcholine Receptors as Drug Targets. Drug Discov. Today 2017, 22, 97–104. [Google Scholar]
Khovpachev, A.A.; Basharin, V.A.; Chepur, S.V.; Volobuev, S.V.; Yudin, M.A.; Gogolevsky, A.S.; Nikiforov, A.S.; Kalinina, L.B.; Tyunin, M.A. Actual Concepts of Higher Fungi’s Toxins: Simple Nitrogen-Containing Compounds. Biol. Bull. Rev. 2021, 11, 198–212. [Google Scholar] [CrossRef]
Parnmen, S.; Nooron, N.; Leudang, S.; Sikaphan, S.; Polputpisatkul, D.; Pringsulaka, O.; Binchai, S.; Rangsiruji, A. Foodborne Illness Caused by Muscarine-Containing Mushrooms and Identification of Mushroom Remnants Using Phylogenetics and LC-MS/MS. Food Control 2021, 128, 108182. [Google Scholar] [CrossRef]
Shen, K.; Johnson, S.W. Presynaptic Dopamine D2 and Muscarine M 3 Receptors Inhibit Excitatory and Inhibitory Transmission to Rat Subthalamic Neurones In Vitro. J. Physiol. 2000, 525, 331–341. [Google Scholar] [CrossRef]
Neely, A.; Lingle, C.J. Effects of Muscarine on Single Rat Adrenal Chromaffin Cells. J. Physiol. 1992, 453, 133–166. [Google Scholar] [CrossRef] [PubMed]
Meng, W.; Wang, S.; Yao, L.; Zhang, N.; Li, D. Muscarinic Receptors Are Responsible for the Cholinergic Modulation of Projection Neurons in the Song Production Brain Nucleus RA of Zebra Finches. Front. Cell. Neurosci. 2017, 11, 51. [Google Scholar] [CrossRef]
Voynova, M.; Shkondrov, A.; Kondeva-Burdina, M.; Krasteva, I. Toxicological and Pharmacological Profile of Amanita muscaria (L.) Lam.—A New Rising Opportunity for Biomedicine. Pharmacia 2020, 67, 317–323. [Google Scholar] [CrossRef]
Stříbrný, J.; Sokol, M.; Merová, B.; Ondra, P. GC/MS Determination of Ibotenic Acid and Muscimol in the Urine of Patients Intoxicated with Amanita pantherina. Int. J. Leg. Med. 2012, 126, 519–524. [Google Scholar] [CrossRef]
Ginterová, P.; Sokolová, B.; Ondra, P.; Znaleziona, J.; Petr, J.; Ševčík, J.; Maier, V. Determination of Mushroom Toxins Ibotenic Acid, Muscimol and Muscarine by Capillary Electrophoresis Coupled with Electrospray Tandem Mass Spectrometry. Talanta 2014, 125, 242–247. [Google Scholar] [CrossRef]
Obermaier, S.; Müller, M. Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation. Angew. Chem. Int. Ed. 2020, 59, 12432–12435. [Google Scholar] [CrossRef]
Nelson, L.E.; Guo, T.Z.; Lu, J.; Saper, C.B.; Franks, N.P.; Maze, M. The Sedative Component of Anesthesia Is Mediated by GABAA Receptors in an Endogenous Sleep Pathway. Nat. Neurosci. 2002, 5, 979–984. [Google Scholar] [CrossRef]
Stebelska, K. Fungal Hallucinogens Psilocin, Ibotenic Acid, and Muscimol: Analytical Methods and Biologic Activities. Ther. Drug Monit. 2013, 35, 420–442. [Google Scholar] [CrossRef] [PubMed]
Vendramin, A.; Brvar, M. Amanita muscaria and Amanita pantherina Poisoning: Two Syndromes. Toxicon 2014, 90, 269–272. [Google Scholar] [CrossRef]
Moss, M.J.; Hendrickson, R.G. Toxicity of Muscimol and Ibotenic Acid Containing Mushrooms Reported to a Regional Poison Control Center from 2002–2016. Clin. Toxicol. 2019, 57, 99–103. [Google Scholar] [CrossRef] [PubMed]
Akirav, I.; Raizel, H.; Maroun, M. Enhancement of Conditioned Fear Extinction by Infusion of the GABAA Agonist Muscimol into the Rat Prefrontal Cortex and Amygdala. Eur. J. Neurosci. 2006, 23, 758–764. [Google Scholar] [CrossRef] [PubMed]
Hobin, J.A.; Ji, J.; Maren, S. Ventral Hippocampal Muscimol Disrupts Context-Specific Fear Memory Retrieval after Extinction in Rats. Hippocampus 2006, 16, 174–182. [Google Scholar] [CrossRef] [PubMed]
Young, S.Z.; Bordey, A. GABA’s Control of Stem and Cancer Cell Proliferation in Adult Neural and Peripheral Niches. Physiology 2009, 24, 171–185. [Google Scholar] [CrossRef] [PubMed]
Tatsuta, M.; Iishi, H.; Baba, M.; Uehara, H.; Nakaizumi, A.; Taniguchi, H. Protection by Muscimol against Gastric Carcinogenesis Induced by N-Methyl-N′-Nitro-N-Nitrosoguanidine in Spontaneously Hypertensive Rats. Int. J. Cancer 1992, 52, 924–927. [Google Scholar] [CrossRef]
Kondeva-Burdina, M.; Voynova, M.; Shkondrov, A.; Aluani, D.; Tzankova, V.; Krasteva, I. Effects of Amanita muscaria Extract on Different in Vitro Neurotoxicity Models at Sub-Cellular and Cellular Levels. Food Chem. Toxicol. 2019, 132, 110687. [Google Scholar] [CrossRef]
Bowden, K.; Drysdale, A.C.; Mogey, G.A. Constituents of Amanita muscaria. Nature 1965, 206, 1359–1360. [Google Scholar] [CrossRef]
Satora, L.; Pach, D.; Butryn, B.; Hydzik, P.; Balicka-Ślusarczyk, B. Fly Agaric (Amanita muscaria) Poisoning, Case Report and Review. Toxicon 2005, 45, 941–943. [Google Scholar] [CrossRef]
Lewis, B. Atropine in Mushrooms; Therapeutic Implications. S. Afr. Med. J. 1955, 29, 262–263. [Google Scholar]
Wieland, T. Poisonous Principles of Mushrooms of the Genus Amanita: Four-Carbon Amines Acting on the Central Nervous System and Cell-Destroying Cyclic Peptides Are Produced. Science 1968, 159, 946–952. [Google Scholar] [CrossRef] [PubMed]
Subbaratnam, A.V.; Cook, W.B. Subsidiary Constituents from Amanita muscaria. J. Med. Chem. 1963, 6, 448–449. [Google Scholar] [CrossRef]
Osbourn, A.E.; Lanzotti, V. (Eds.) Plant-Derived Natural Products; Springer: New York, NY, USA, 2009; ISBN 978-0-387-85497-7. [Google Scholar]
Volgin, A.D.; Yakovlev, O.A.; Demin, K.A.; Alekseeva, P.A.; Kalueff, A.V. Acute Behavioral Effects of Deliriant Hallucinogens Atropine and Scopolamine in Adult Zebrafish. Behav. Brain Res. 2019, 359, 274–280. [Google Scholar] [CrossRef] [PubMed]
Debnath, B.; Singh, W.S.; Das, M.; Goswami, S.; Singh, M.K.; Maiti, D.; Manna, K. Role of Plant Alkaloids on Human Health: A Review of Biological Activities. Mater. Today Chem. 2018, 9, 56–72. [Google Scholar] [CrossRef]
Yamin-Pasternak, S.; Pasternak, I. Ethnomycology. In The International Encyclopedia of Anthropology; Callan, H., Ed.; Wiley: Hoboken, NJ, USA, 2018; pp. 1–2. ISBN 978-1-118-92439-6. [Google Scholar]
Comandini, O.; Rinaldi, A.C. Ethnomycology in Europe: The Past, the Present, and the Future. In Mushrooms, Humans and Nature in a Changing World; Pérez-Moreno, J., Guerin-Laguette, A., Flores Arzú, R., Yu, F.-Q., Eds.; Springer International Publishing: Cham, Switzerland, 2020; pp. 341–364. ISBN 978-3-030-37377-1. [Google Scholar]
Wieczorek, M. The Effect of Particular Active Substances of Hallucinogenic Mushrooms. Acta Univ. Lodz. Folia Biol. Oecol. 2014, 10, 40–48. [Google Scholar] [CrossRef]
Ruck, C.A.P.; Hoffman, M.A.; González Celdrán, J.A. Mushrooms, Myth, & Mithras: The Drug Cult That Civilized Europe; City Lights Books: San Francisco, CA, USA, 2011; ISBN 978-0-87286-470-2. [Google Scholar]
Lee, M.; Dukan, E.; Milne, I. Amanita muscaria (Fly Agaric): From a Shamanistic Hallucinogen to the Search for Acetylcholine. J. R. Coll. Physicians Edinb. 2018, 48, 85–91. [Google Scholar] [CrossRef]
Nyberg, H. Religious Use of Hallucinogenic Fungi: A Comparison between Siberian and Mesoamerican Cultures. Karstenia 1992, 32, 71–80. [Google Scholar] [CrossRef]
Cunningham, N. Hallucinogenic Plants of Abuse. Emerg. Med. Australas. 2008, 20, 167–174. [Google Scholar] [CrossRef]
Lowy, B. Amanita muscaria and the Thunderbolt Legend in Guatemala and Mexico. Mycologia 1974, 66, 188–191. [Google Scholar] [CrossRef]
Wasson, R.G. The Soma of the Rig Veda: What Was It? J. Am. Orient. Soc. 1971, 91, 169. [Google Scholar] [CrossRef]
Wasson, R.G. Soma Brought Up-to-Date. J. Am. Orient. Soc. 1979, 99, 100. [Google Scholar] [CrossRef]
Wasson, R.G. Soma: Divine Mushroom of Immortality; Ethno-mycological studies; Mouton: The Hague, The Netherlands, 1968; ISBN 978-0-15-683800-9. [Google Scholar]
Feeney, K. Revisiting Wasson’s Soma: Exploring the Effects of Preparation on the Chemistry of Amanita muscaria. J. Psychoact. Drugs 2010, 42, 499–506. [Google Scholar] [CrossRef]
Skarstein Kolberg, A. Did Vikings Really Go Berserk? An Interdisciplinary Critical Analysis of Berserks. J. Mil. Hist. 2018, 82, 899–908. [Google Scholar]
Fatur, K. Sagas of the Solanaceae: Speculative Ethnobotanical Perspectives on the Norse Berserkers. J. Ethnopharmacol. 2019, 244, 112151. [Google Scholar] [CrossRef] [PubMed]
Rätsch, C.; Müller-Ebeling, C. Pagan Christmas: The Plants, Spirits, and Rituals at the Origins of Yuletide, 1st ed.; Inner Traditions: Rochester, VT, USA, 2006; ISBN 978-1-59477-092-0. [Google Scholar]
Hijmans, S. Sol Invictus, the Winter Solstice, and the Origins of Christmas. Mouseion 2003, 3, 377–398. [Google Scholar] [CrossRef]
Marley, G.A. Chanterelle Dreams, Amanita Nightmares: The Love, Lore, and Mystique of Mushrooms; Chelsea Green Pub: White River Junction, VT, USA, 2010; ISBN 978-1-60358-214-8. [Google Scholar]
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